Fig. 6.

Brusatol does not provoke the general depletion of short-half-life proteins in Hepa-1c1c7 cells. Cyclin A, HIF-1α, p53, and survivin protein levels in whole-cell lysates prepared from Hepa-1c1c7 cells exposed to 300 nM brusatol for the indicated times are shown, as determined by immunoblotting. All blots shown are representative of three independent experiments.