FIG. 2.
(A) Metastatic count (NM). Number of grossly visible metastases was counted without magnification. After 8 weeks, animals with CS-derived tumors had developed more metastases (NM=42) compared with animals with ICS-derived tumors (NM=19). The total metastatic count was >405 among animals (n=5) in the 12-week CS group and 161 for animals (n=5) within the 12-week ICS group. (B) Pattern of metastatic spread after 8 and 12 weeks. Metastatic progression based on the organs affected was analyzed on comparing the ICS versus CS transplantation groups after 8 and 12 weeks of tumor growth, respectively. (C) Metastases formed after 8 weeks in animals bearing ID8 CS-derived tumors. Scale bar is 50 μm (×200). (a) Diaphragm, (b) kidney, (c) liver, and (d) peritoneum. Color images available online at www.liebertpub.com/tec