FIG. 5.

Fibroblast activation protein (FAP) and matrix metalloproteinase-2 (MMP-2) expression. Scale bar is 50 μm (×200). (a) shows FAP-positive cells stained in brown (arrow) at 1 week in CS-derived tumor. (b) shows MMP-2-positive stroma stained in brown (arrow) at 1 week in CS-derived tumor. (c, d) show positive expression for FAP, MMP-2 at 8 weeks in CS-derived tumors (arrow). (e, f ) show a decrease in FAP, MMP-2 after 12 weeks of CS-derived tumor growth (arrow). (g, h) show low FAP, MMP-2 expression at 8 weeks for ICS tumors (arrow). (i, j) show decreased FAP, MMP-2 expression after 12 weeks of ICS tumor growth. Color images available online at www.liebertpub.com/tec