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. Author manuscript; available in PMC: 2015 Feb 6.
Published in final edited form as: Sci Transl Med. 2014 Aug 6;6(248):248ra105. doi: 10.1126/scitranslmed.3009246

Fig. 6. Effect of APT102 and clopidogrel on myocardial tissue after ischemia-reperfusion injury in mice.

Fig. 6

C57BL/6J mice were given equivalent volumes of saline (intravenously as a control) or APT102 (1.0 mg/kg, intravenously) 5 min before or 50 min after the onset of 60 min of ischemia (via LAD coronary occlusion), clopidogrel (10.0 mg/kg, orally) pretreatment 24 hours before ischemia, or a combination of clopidogrel pretreatment and APT102 5 min before ischemia. Bars represent means ± SEM. Control, n = 12; APT102 before ischemia, n = 12; APT102 after ischemia, n = 30; clopidogrel, n = 15; clopidogrel plus APT102, n = 33. *P < 0.05, **P < 0.0005, ***P < 0.0001, ****P < 0.00001 by t tests.