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Generation of mouse chimeras by 8-cell embryo coculture with ESCs. Morulae developed from ESC coculture ((a) bright field; (b) GFP fluorescence); the arrow shows that ESCs were aggregated into the recipient embryos. Blastocysts developed from ESC coculture in the WOW system ((c) bright field; (d) GFP fluorescence). The arrow shows how ESCs were aggregated into the ICM of recipient embryos.
