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Generation of chimeric mice using iPSCs.
| Method | Number of embryos transferred | Number of recipients | Number of pregnant recipients (%) |
Number of pups | Number of chimeras (%) |
|---|---|---|---|---|---|
| 8-cell coculture | 341 | 16 | 1 (6.3)a | 1 | 0 (0) |
| 8-cell injection | 192 | 11 | 10 (90.9)b | 58 | 8 (13.8)a |
| Blastocyst injection | 287 | 14 | 9 (64.3)b | 83 | 0 (0)b |
|
| |||||
| Total | 820 | 41 | 20 (48.8) | 142 | 8 (5.6) |
a,bValues with different superscripts within the same column are significantly different (P < 0.05).
