FIG. 8.

The proposed cross-talk between MLO-A5 and 10T-GFP cells. Co-cultured MLO-A5 and 10T-GFP cells may exchange small molecular messengers through gap junctions, leading to the acetylation of core histones in 10T-GFP cells. These modifications increase chromatin accessibility by relaxing chromatin condensation, enabling transcription factors to bind to the genomic DNA and modify transcription. The identities of these transcription factors and the signaling pathways they activate remain to be determined.