Table 3. Susceptibility Interpretation of Broth Microdilution Test.
NTM species | M. abscessus | M. massiliense | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Antibiotics | Day 3 | Day 5 | Day 3 | Day 5 | ||||||||
MIC*range | %SI※ | MIC90# | MIC range | %SI | MIC90 | MIC range | %SI | MIC90 | MIC range | %SI | MIC90 | |
Amikacin (AMK) | 8 to 16 | 100 | 16 | 8 to 16 | 100 | 16 | 8 to >32 | 90.9 | 32 | 8 to >32 | 90.9 | 32 |
Ciprofloxacin (CPF) | 4 to 32 | 0 | 32 | 8 to >32 | 0 | >32 | 1 to >32 | 27.3 | 8 | 4 to >32 | 0 | 32 |
Levofloxacin (LVF) | 16 to 32 | 0 | 32 | 32 to >32 | 0 | >32 | 8 to 32 | 0 | 32 | 16 to >32 | 0 | >32 |
Moxifloxacin (MXF) | 4 to 16 | 0 | 16 | 8 to 32 | 0 | 32 | 1 to 16 | 9.1 | 16 | 4 to >32 | 0 | 32 |
Gatifloxacin (GAF) | 1 to 16 | 30.7 | 8 | 8 to 32 | 0 | 32 | 1 to 16 | 18.2 | 8 | 16 to 32 | 0 | 32 |
Antimicrobial MIC break points (S,I,R): AMK(16,32,64); CPF(1,2,4); LVF(1,2,4); MXF(1,2,4); GAF(1,2,4) (μg/mL) (S, I, R: susceptible, intermediate susceptible and resistant)
*MIC(μg/mL): minimum inhibitory concentration
※%SI: percentage of susceptible or intermediate susceptible to antibiotics
#MIC90: MIC required to inhibit the growth of 90% of the organism