Table III.

Characteristics of case-control GWAS studies and SNPs associated with chronic diseases at p<5×10⁻⁸.

MeSHa Disease or Disorder Category	Number of Studies	Median (Range) SNPs Passing QCb, (Thousands)	Median (Range) Sample Sizec	Number of Independent SNPsd	Median (Range) Control Minor Allele Frequency	Median (Range) Odds Ratio
All	219	541 (80 – 7,689)	15,722 (225 – 143,503)	729	0.29 (0.01 – 0.50)	1.26 (1.06 – 6.23)
Cardiovascular diseases	22	2,500 (289 – 2,500)	31,210 (225 – 143,503)	72	0.25 (0.01 – 0.49)	1.19 (1.06 – 4.82)
Digestive system diseases	20	523 (266 – 2,466)	25,885 (895 – 48,950)	138	0.30 (0.04 – 0.50)	1.21 (1.07 – 6.23)
Eye, otorhinolaryngologic, and stomatognathic diseases ("Sensory organ diseases")	15	524 (299 – 6,037)	10,462 (690 – 64,542)	36	0.31 (0.01 – 0.50)	1.38 (1.15 – 5.47)
Mental disorders	6	1,253 (315 – 2,415)	51,695 (2,672 – 63,649)	16	0.17 (0.06 – 0.46)	1.20 (1.12 – 1.59)
Musculoskeletal diseases	20	1,585 (80 – 2,716)	12,126 (1,606 – 47,926)	64	0.29 (0.05 – 0.50)	1.30 (1.10 – 3.62)
Neoplasms	61	541 (247 – 7,689)	12,218 (1,920 – 71,531)	160	0.31 (0.02 – 0.50)	1.29 (1.11 – 2.22)
Nervous system diseases	30	531 (131 – 7,689)	14,175 (1,208 – 102,338)	84	0.26 (0.03 – 0.48)	1.24 (1.09 – 5.11)
Nutritional, metabolic, and endocrine diseases	12	2,427 (207 – 2,626)	58,587 (792 – 141,454)	43	0.32 (0.06 – 0.50)	1.11 (1.06 – 4.05)
Respiratory tract diseases	7	459 (215 – 550)	35,083 (1,711 – 57,800)	21	0.36 (0.14 – 0.50)	1.20 (1.09 – 1.25)
Skin and connective tissue diseases	18	495 (299 – 6,037)	12,454 (3,107 – 51,423)	72	0.28 (0.04 – 0.50)	1.30 (1.11 – 2.80)
Urogenital diseases	8	498 (303 – 2,187)	10,769 (1,641 – 46,283)	23	0.24 (0.06 – 0.50)	1.34 (1.20 – 2.86)

^aMeSH: Medical Subject Heading.

^bThe number of SNPs passing quality control (QC) in the first GWAS stage.

^cThe number of cases and controls in all stages.

^dThe sum of independent SNPs (r²<0.5) associated with each disease.