Table IV.
Characteristics of case-control GWAS SNPs associated with chronic diseases at p<5×10−8, by odds ratio (OR) and minor allele frequency (MAF).
| Odds Ratio | Minor Allele Frequency (MAF) |
Number of Independent SNPsa |
Median (Range) SNPs Passing QCb, (Thousands) |
Median (Range) Sample Sizec |
|---|---|---|---|---|
| 1.0≤OR<1.5 | 0.01<MAF≤0.1 | 25 | 666 (300 –7,689) | 26,005 (6,089 – 143,503) |
| 0.1<MAF≤0.3 | 250 | 570 (80 – 7,689) | 23,422 (4,644 – 143,403) | |
| 0.3<MAF≤0.5 | 312 | 541 (131 – 7,689) | 20,916 (1,607 – 143,503) | |
| OR≥1.5 | 0.01<MAF≤0.1 | 35 | 666 (282 – 7,689) | 10,769 (1,606 – 143,503) |
| 0.1<MAF≤0.3 | 68 | 501 (235 – 6,607) | 7,354 (690 – 74,544) | |
| 0.3<MAF≤0.5 | 39 | 480 (215 – 2,500) | 3,424 (225 – 39,547) | |
a
The sum of independent SNPs (r2<0.5) associated with each disease.
b
The number of SNPs passing quality control (QC) in the first GWAS stage.
c
The number of cases and controls in all stages.