Table V.
Relative heritability that can be explained by SNPs detectable by GWAS
| Disease | λsa | Previous GWAS |
Imputed | Illm5M | All 1KGP | Nx2 | Nx4 | Imputed Nx4 |
Illm5M Nx4 |
All 1kGP Nx4 |
|---|---|---|---|---|---|---|---|---|---|---|
| Asthma | 2.6 | 7 | 8 | 9 | 13 | 24 | 59 | 62 | 72 | 88 |
| Breast cancer | 2.5 | 10 | 12 | 14 | 18 | 30 | 58 | 66 | 77 | 90 |
| Coronary heart disease | 3.2 | 13 | 15 | 15 | 21 | 30 | 57 | 66 | 75 | 90 |
| Crohn’s disease | 26.0 | 24 | 27 | 25 | 38 | 53 | 74 | 79 | 90 | 99 |
| Prostate cancer | 2.8 | 15 | 17 | 18 | 25 | 33 | 58 | 69 | 79 | 93 |
| Rheumatoid arthritis | 8.0 | 40 | 41 | 44 | 51 | 53 | 67 | 72 | 89 | 99 |
| Systemic lupus erythematosus | 30.0 | 12 | 13 | 16 | 21 | 33 | 62 | 66 | 76 | 91 |
| Type 2 diabetes | 3.5 | 14 | 15 | 16 | 22 | 40 | 67 | 75 | 83 | 99 |
a
λs: Sibling recurrence risk ratio. Source of λs for Asthma: Hemminki et al., 2007; Breast cancer: Risch, 2001; Coronary heart disease: Marenberg et al., 1994; Crohn’s disease: WTCCC, 2007; Prostate cancer: Risch, 2001; Rheumatoid arthritis: Harney and Wordsworth, 2002; Systemic lupus erythematosus: Harley et al., 2008; Type 2 diabetes: Das and Elbein, 2006.