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. 2014 Oct 16;70(2):463–469. doi: 10.1093/jac/dku403

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© The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — View from an NDM-1 crystal structure with hydrolysed methicillin (PDB code: 4EY2) showing the positions of the identified substitutions relative to the active site: NDM-3, D95N; NDM-4, M154L; NDM-5, V88L and M154L; NDM-6, A233V; NDM-7, D130N and M154L; and NDM-8, D130G and M154L. Pink spheres indicate the two zinc ions.