Table 1.

Bundle elements in patients with candidaemia

Bundles to be accomplished at the start of therapy

1. Removal of existing CVCs within 24 h of diagnosis

2. Initial appropriate selection of antifungals

3. Initial appropriate dosing of antifungals

Bundles to be accomplished after initiation of therapy

4. Ophthalmological examinations

5. Follow-up blood cultures until clearance of candidaemia

6. Assessment of clinical efficacy on the third to fifth day to consider necessity of alternative therapy

7. Appropriate choice of alternative antifungals

8. At least 2 weeks of therapy after documented clearance of Candida from bloodstream and resolution of attributable symptoms (prolonged therapy for candidaemia with organ involvement)

9. Step-down oral therapy for patients with favourable clinical course