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. 2014 Sep 30;24(3):828–840. doi: 10.1093/hmg/ddu500

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© The Author 2014. Published by Oxford University Press

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Increased nuclear invaginations and elevated Histone H3 K9 trimethylation in Aptx−/− SOD1^G93A neurons. (A) Representative transmission electron microscopy (TEM) images of motor neurons prepared for ultrastructural analysis from 3-month-old WT, Aptx−/−, SOD1^G93A and Aptx−/− SOD1^G93A mice. Scale bar = 5 μm. (b) The average nuclear area occupied by high-density nuclear regions was quantified from ∼70 neurons obtained from three independent litters. Data are the average ± SEM. (C) Representative TEM images of H3 K9 trimethylation revealed by immunogold labelling of motor neurons from 3-month-old Aptx−/− SOD1^G93A mouse. Scale bar = 2 μm (top) and 0.2 μm (bottom). (D) Average nuclear area occupied by the anti-Histone H3 (trimethyl K9)-positive dense chromatin within the indicated genetic backgrounds was quantified from 30 neurons obtained from three independent litters. Data are the average ± SEM.