Figure 6.
Aptx−/− SOD1G93A mice feature molecular hallmarks of organismal ageing. Electrophoretic analysis of the products of RT-PCR amplification of β-actin (control) and insulin-like growth factor (IGF-1) from mRNA extracted from liver of 3-month-old WT, Aptx−/−, SOD1G93A and Aptx−/− SOD1G93A mice. A representative image is depicted in (A) and quantification of the fold change in IGF-1 levels (by qPCR) relative to the level observed in WT mice is shown in (B). Data are the average of three independent replicates ± SEM.