TABLE 1.
Selection of nitroimidazole-resistant mutants after 8 weeks of monotherapy in experiment 1
| Drug, dose (mg/kg) | Mean lung log10 CFU (± SD) | % CFU (no. of mice with isolates) resistant to: |
||
|---|---|---|---|---|
| 1 μg/ml PA-824 | 0.25 μg/ml delamanid | 0.25 μg/ml TBA-354 | ||
| PA-824, 300 | 4.16 ± 0.43 | 48 (1) | ||
| 67–100 (3) | ||||
| PA-824, 600 | 4.17 ± 0.43 | 80–100 (3)a | ||
| Delamanid, 30 | 5.19 ± 0.01 | 0.3–1.3 (3) | ||
| 7 (1) | ||||
| Delamanid, 100 | 4.91 ± 0.21 | 0.01 (1) | ||
| 20–22 (3) | ||||
| TBA-354, 10 | 4.70 ± 0.24 | 2–20 (3)a | ||
| TBA-354, 30 | 4.75 ± 0.47 | 1–10 (4) | ||
| TBA-354, 100 | 3.83 ± 0.32 | 34 (1) | ||
| 87–100 (3) | ||||
a
The isolate from 1 of 4 mice was unevaluable due to contamination of the culture.