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Metabolic stability of TBA-354 in hepatocytes. TBA-354 at 1 μM was incubated with mouse (■), rat (△), rabbit (□), dog (○), monkey (▲), or human (●) hepatocytes (at ca. 1 × 106 cells/ml) at 37°C for 4 h. The metabolic stability of TBA-354 was assessed based on the relative concentrations of the remaining TBA-354 at 0.5, 1, 2, and 4 h compared to TBA-354 at 0 h.
