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Single-dose pharmacokinetics of TBA-354 in mice. TBA-354 was administered to female BALB/c mice by oral gavage (p.o.) at 3, 30, and 100 mg/kg, formulated in 0.5% carboxymethylcellulose (CMC), and at 2 mg/kg (formulated in 40% hydroxypropyl-β-cyclodextrin and 50 mM citrate buffer at pH 3) by i.v. bolus. Plasma samples were collected from three mice per time point and TBA-354 concentrations were determined by LC-MS/MS.
