FIG 3.

Efficacy of 100 mg/kg TBA-354 against acute and chronic TB in mice. (a) Acute infection model: inoculum was determined 3 days after infection. Treatment with vehicle or 100 mg/kg/day each nitroimidazole for 3 weeks, 5 days per week, commenced at day 10 postinfection (Start of treatment [Tx]) and terminated at day 28 postinfection. CFU were determined, after a 3-day washout period, at day 31 postinfection, for vehicle- and nitroimidazole-treated mice. (b) Chronic infection model: inoculum was determined 4 days postinfection. Treatment with vehicle or 100 mg/kg/day each nitroimidazole for 3 weeks, 5 days per week, started 70 days postinfection (Start of Tx) and ended at day 88 postinfection. CFU were determined, after a 3-day washout period, at day 91 postinfection, for vehicle- and nitroimidazole-treated mice. Data were previously expressed as CFU reduction and relative reduction compared to that for Pa (23).