TABLE 4.
Pharmacokinetics of JPC-2997 in healthy mice administered single oral doses of JPC-2997 between 2.5 and 40 mg/kg
| Dose (mg/kg) | Concn at 1 ha (μg/liter) | Concn/dose (%) | AUC/dose (%) | AUC (μg · h/liter) | t1/2 (h) | V/F (liters/kg) | CL/F (liters/h/kg) |
|---|---|---|---|---|---|---|---|
| 2.5 | 288 | 0.38 | 16.7 | 12,555 | 60.1 | 17.3 | 0.20 |
| 5 | 753 | 0.5 | 17.5 | 26,213 | 48 | 13.2 | 0.19 |
| 10 | 1,013 | 0.34 | 14 | 41,847 | 53.5 | 18.5 | 0.24 |
| 20 | 2,067 | 0.34 | 15.1 | 90,370 | 40.1 | 12.8 | 0.22 |
| 40 | 3,235 | 0.27 | 13.9 | 166,370 | 47.4 | 16.4 | 0.24 |
| Mean ± SD | 0.37 ± 0.08 | 15.4 ± 1.6 | 49.8 ± 7.5 | 15.6 ± 2.5 | 0.22 ± 0.02 |
a
Highest plasma JPC-2997 concentration measured with the bleed schedule used.