FIG 1.
Concentration-response effects of tedizolid and linezolid on MPS. Highly coupled rat heart mitochondria were incubated with [35S]methionine in the presence of increasing concentrations of tedizolid (open circles) or linezolid (closed circles). Data are the means (± standard errors of the means) from six independent experiments. IC50 is defined as the concentration of drug causing a 50% reduction of the value for the control (vehicle only), with its value calculated using best-fit hyperbolic decay regression.