TABLE 3.

Protein binding rates for the six vancomycin products in pooled mouse and human sera^a

Serum	Vancomycin concn (mg/liter)	Binding rate (% ± 1 SD) for vancomycin product:
		A	B	C	D	E	F
Mouse	1	43.1 ± 9.9	46.8 ± 4.3	43.0 ± 8.3	44.7 ± 4.4	40.9 ± 3.7	40.6 ± 6.5
	60	43.6 ± 6.9	44.0 ± 5.5	47.9 ± 2.8	35.7 ± 4.2	46.9 ± 3.2	43.1 ± 3.4
	300	47.5 ± 11.0	40.3 ± 13.4	50.9 ± 5.7	45.1 ± 4.5	48.4 ± 4.0	45.9 ± 5.6
Mean binding rate		44.7 ± 9.3	43.7 ± 7.7	47.3 ± 5.6	41.8 ± 4.4	45.4 ± 3.7	43.2 ± 5.2
Human	1	40.1 ± 6.4	35.6 ± 9.2	42.4 ± 3.1	37.4 ± 8.7	33.1 ± 6.1	35.1 ± 5.7
	60	41.3 ± 7.1	37.0 ± 1.6	35.6 ± 4.2	33.3 ± 4.4	35.7 ± 2.8	32.2 ± 5.5
	300	27.9 ± 6.2	33.3 ± 8.4	32.4 ± 4.8	30.7 ± 8.1	34.6 ± 2.6	42.9 ± 5.5
Mean binding rate		36.4 ± 6.5	35.3 ± 6.4	36.8 ± 4.1	33.8 ± 7.1	34.5 ± 3.9	36.7 ± 5.6

^aThe protein binding experiments were conducted in duplicate on two separate days (four samples for each vancomycin product and dose).