TABLE 2.
Final population PK model parameter estimates and standard errors
| Parametera | Final estimated mean value (% SEM) |
|
|---|---|---|
| Population mean | Magnitude of interindividual variability (CV %) | |
| Vcu (liters) | 66.1 (18.6) | 139 (29.4) |
| Vp1u (liters) | 582 (7.51) | 48.0 (17.3) |
| CLd1u (liters/h) | 60.8 (11.0) | 35.1 (30.4) |
| Vp2u (liters) | 211 (10.2) | 64.5 (19.0) |
| CLd2u (liters/h) | 199 (10.1) | 39.3 (25.8) |
| CLtu (liters/h) | 120 (4.04) | 17.8 (14.4) |
| Bmax | 12.7 | |
| KD | 2.07 | |
| SDin | 0.0005 | |
| SDsl | 0.217 (2.62) | |
a
Volumes and clearances are scaled to free-drug concentrations. The minimum value of the objective function is −1,888. Vp1u, volume of distribution of the first peripheral compartment; Vp2u, volume of distribution of the second peripheral compartment; CLd2u, second distributional clearance; Bmax, parameter describing the maximum extent of protein binding; SDin, intercept (additive) term for residual variability model for plasma concentrations; SDsl, slope (proportional) term for residual variability model.