FIG 2.

Lesion size increases as the time between infection and therapy increases. BALB/c mice (n = 5) were infected i.d. with 5 × 10⁷ CFU S. aureus SF8300. Treatment with VAN (A), LZD (B), or MEDI4893* (C) was initiated at 1, 2, 3, or 4 h postinfection. Antibiotics were also dosed again at 8 h postinfection. Lesion sizes were measured at 24 h postinfection. Results with the isotype control R347 (black bars) are shown for comparison. Lesion size differences were calculated with an unpaired t test and considered statistically significant if the P value was <0.05 (*). Results are representative of 3 independent experiments.