FIG 3.
Adjunctive therapy with MEDI4893*-vancomycin or MEDI4893*-linezolid reduces lesion size. BALB/c mice (n = 10) were infected i.d. with 5 × 107CFU S. aureus SF8300 and treated at 3 h postinfection with VAN (200 mg/kg/day), LZD (10 mg/kg/day), MEDI4893* (2.5 mg/kg), R347 (15 mg/kg), or a combination of VAN (200 mg/kg/day) plus MEDI4893* (2.5 mg/kg) or LZD (10 mg/kg/day) plus MEDI4893* (2.5 mg/kg). MEDI4893* was administered once, and antibiotic treatment was continued at 8, 24, and 32 h postinfection. Lesions were measured (A) and photographed (B) at 24, 72, and 168 h postinfection. Lesion size differences were calculated with Student's t test and considered statistically significant if the P value was <0.05 (*). Results from 2 independent studies were pooled.