FIG 4.

The addition of MEDI4893* to antibiotic therapy increases IL-1β in skin lesions. Mice were challenged and treated as described in the legend to Fig. 3. At 24 h postinfection, skin lesions were collected and processed as described in Materials and Methods to measure IL-1β levels. Lesion size differences were calculated with Student's t test and considered statistically significant if the P value was <0.05 (*). Results are representative of 3 independent experiments.