TABLE 1.
Plasma pharmacokinetic/pharmacodynamic parameters for vancomycin and linezolid
| Drug | Dose (mg/kg) | MIC (μg/ml) | Tmaxa (h) | t1/2 (h) | fCmaxb (μg/ml) | fAUC0–∞b (μg · h/ml) | fAUC/MIC |
|---|---|---|---|---|---|---|---|
| Vancomycin | 100 | 0.5 | 0.5 | 0.45 | 121.5 | 224.4 | 448.8 |
| Linezolid | 5 | 1.0 | 0.25 | 0.95 | 14.4 | 24.3 | 24.3 |
a
Tmax, time to maximum concentration of drug in plasma.
b
The free-drug exposure following a single 100-mg/kg i.p. dose of vancomycin or a single 5-mg/kg subcutaneous dose of linezolid was determined from the total drug plasma levels corrected for protein binding.