TABLE 2.
Effects of H51Y and R262K substitutions on EC50s for DTG and RAL in cell-based assaysa
| Genotype | DTG |
RAL |
||
|---|---|---|---|---|
| EC50 (mean ± SD) (nM) | FC | EC50 (mean ± SD) (nM) | FC | |
| WT | 3.23 ± 1.06 | 1.00 | 0.16 ± 1.25 | 1.00 |
| H51Y | 4.02 ± 1.25 | 1.24 | 0.15 ± 1.16 | 0.98 |
| H51Y/R262K | 6.05 ± 1.09 | 1.87b | 0.14 ± 1.35 | 0.92 |
a
The effects of the primary INSTI resistance substitutions H51Y and R262K on the EC50 values for DTG and RAL were determined in cell culture assays. DTG EC50 values are representative of three independent experiments. RAL EC50 values are representative of two independent experiments. SD, standard deviation.
b
P < 0.05.