FIG 4.

In vivo antileishmanial activity of free and SSG-encapsulated PC-DDAB liposomes. (A, B, D, and E) Therapeutic effects of drugs were analyzed as reductions in weight and Leishman-Donovan units (LDU) in liver (A and D) and spleen (B and E) of AG83-infected (A and B) and GE1F8R-infected (D and E) mice. (C and F) Bone marrow parasite loads of AG83 (C) and GE1F8R (F) were expressed as amastigotes per 1,000 bone marrow nuclei. Values are means ± standard errors (n = 5) of two independent experiments. *, P < 0.05 versus control for organ weight and versus PC-DDAB for LDU, by ANOVA.