TABLE 1.
Demographic and laboratory summary statistics for study subjects
| Statistic | Results for group (no.)a: |
Pb | |
|---|---|---|---|
| A (9) | B (8) | ||
| Age (y) | 29.8 (23.5–45.1) | 28.2 (20.0–49.4) | 0.564 |
| Weight (kg) | 54 (47–64) | 59 (50–62) | 0.211 |
| Height (cm) | 157 (140–178) | 171 (155–180) | 0.073 |
| Male/female | 2/7 | 6/2 | 0.057 |
| Hemoglobin (g/dl) | 12.3 (11.0–14.7) | 14.3 (11.6–15.9) | 0.034 |
| Glucose (mg/dl) | 83 (67–97) | 84 (78–92) | 0.847 |
| Blood urea nitrogen (mg/dl) | 10.8 (7.5–15.6) | 10.8 (9.1–12.8) | 0.630 |
| Creatinine (mg/dl) | 0.7 (0.5–1.0) | 0.9 (0.7–1.0) | 0.043 |
| Albumin (g/dl) | 4.5 (4.2–4.7) | 4.7 (4.4–5.0) | 0.033 |
| Methemoglobin (%) | 1.1 (0.5–1.8) | 0.95 (0.5–1.5) | 0.590 |
a
Values are reported as medians (minimum to maximum) and as number of male/female subjects. Group A received primaquine alone (visit 1), pyronaridine-artesunate alone, (visit 2) and the combination of pyronaridine-artesunate + primaquine (visit 3). Group B received primaquine alone (visit 1), the combination of pyronaridine-artesunate + primaquine (visit 2), and pyronaridine-artesunate alone (visit 3).
b
P values were calculated using the Mann-Whitney U test, except that for male/female, which was calculated using Fisher's exact test.