TABLE 1.
Overview of experimental design
| Group | Tedizolid phosphate dose (mg/kg/day) |
No. of animals |
||||
|---|---|---|---|---|---|---|
| Neurotoxicity assessmenta |
Toxicokinetic evaluationb |
|||||
| Males | Females | Males | Females | Males | Females | |
| Control | 0 | 0 | 60 | 60 | 5 | 5 |
| Low dose | 7.5 | 2.5 | 36 | 36 | 9 | 9 |
| Medium dose | 15 | 5 | 60 | 60 | 9 | 9 |
| High dose | 30 | 10 | 60 | 60 | 9 | 9 |
a
Up to 12 rats/sex/group were killed at 1 month (control and medium- and high-dose groups), 3 months (all groups), 6 months (all groups), and 9 months (control and medium- and high-dose groups) of dose administration. In addition, up to 12 rats/sex/group (all groups) were killed after 6 months of dose administration and a 3-month recovery (no-dosing) period.
b
All surviving toxicokinetic animals were killed after 9 months of dose administration (3 rats/sex/time point were used for analysis).