TABLE 4.

Plasma exposure of tedizolid after oral administration of tedizolid phosphate to rats over 9 months

Dosing duration	AUC0–24a (μg · h/ml) by sex and dose (mg/kg/day)
	Males			Females
	7.5	15	30	2.5	5	10
1 day	16.9	32.4	69.9	24.9	55.7	95.6
1 mo	20.9	45.8	85.2	26.1	52.0	97.8
3 mo	27.2	81.8	145	34.3	82.6	147
6 mo	34.1	82.7	204	45.8	97.1	174
9 mo	41.9	101	222	51.7	97.2	189

^aAUC_0–24, area under the concentration-time curve from time zero to 24 h.