TABLE 3.
Effect size of individual drug treatmentsa
| Effect size | Drug(s) (dose) | Effect size (95% CI) |
|---|---|---|
| Total | ATV (0.3 mg/kg) | 100 (96–100) |
| PQ (6 mg/kg) | 100 (96–100) | |
| NITD609 (8.1 mg/kg) | 100 (96–100) | |
| PQ (12 mg/kg) | 100 (58–100) | |
| A-L and PQ (12 mg/kg) | 100 (58–100) | |
| Moderate | A-L (57 and 11.8 mg/kg) | 58 (19–86) |
| OZ439 (6.5 mg/kg) | 57 (31–75) | |
| A-L and PQ (0.25 mg/kg) | 42 (20–99) | |
| PQ (1.25 mg/kg) | 29 (−29–69) | |
| Low | PQ (0.25 mg/kg) | 8 (−18–48) |
| SD (8.4 mg/kg) | −0.1 (−0.8–0.3) |
a
Drug treatments have been ranked in order of effect size and transmission-blocking efficacy. Treatments have been broadly divided into three groups: drugs with total (100%) effect size, drugs with a moderate effect size, and drugs with a low effect size. ATV, atovaquone; PQ, primaquine; A-L, artemether-lumefantrine; SD, sulfadiazine.