FIG 5.

Effects of double combinations of CDV (topical plus parenteral treatment) and triple therapy (by adding VIG) on survival rates (A), body weights (B), primary lesion areas (C), and numbers of satellite lesions (D) during a cutaneous vaccinia virus infection in SHO (SCID hairless) mice. The treatment regimens were the same as those described for Fig. 1 except that no cyclophosphamide was given. Standard error bars are shown in panels B, C, and D. Ten mice were in each treatment group. *, P < 0.05, **, P < 0.01, and ***, P < 0.001 (all compared to placebo).