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Resistance selection with DOR, EFV, and RPV in subtype C virus using MT4-GFP/CCR5 cells in the presence 10% FBS
| NNRTI | Pathway | Evolution of mutants as NNRTI concn increases |
|---|---|---|
| DOR | 1 | V106A → V106A/F227I |
| 2 | V106 M → V106 M/F227C | |
| EFV | 1 | L100I → L100I/V106 M → L100I/V106 M/Y188C |
| or F227C | ||
| 2 | V106 M → V106 M/Y188C | |
| RPV | 1 | E138K → E138K/K101E |
| 2 | L100V/M230I → L100V/M230I/F227C | |
| 3 | E138Q → E138Q/L100I |
