FIG 2.

Analysis of the interaction of miravirsen with IFN-α2b (A), RBV (B), VX-222 (C), BMS-790052 (D), telaprevir (E), and 2′-MeC (F) by the method of Prichard and Shipman, Jr., using Macsynergy II, v1.0 (36). Eight successive 2-fold dilutions of miravirsen were evaluated alone or in all possible combinations with five successive 2- or 5-fold serial dilutions of a second compound. Calculated independent effects were subtracted from the observed combined effects. Volumes with positive values at the 95% confidence interval indicate synergy, while volumes with negative values indicate antagonism. Data are from one representative experiment. Conc., concentration.