TABLE 2.
Antiviral susceptibilities of HCV genotype 1b replicons containing mutations in NS3, NS5B, and NS5A proteins
| Compound | Fold changea |
||||
|---|---|---|---|---|---|
| NS3 A156T | NS3 R155K | NS5B S282T | NS5B M423I | NS5A Y93H | |
| Miravirsen | 1.0 | 1.2 | 1.9 | 1.7 | 0.9 |
| Telaprevir | 36.1 | 4.6 | 1.0 | NT | NT |
| 2′-MeC | 0.9 | 0.8 | 45.8 | 1.0 | 1.0 |
| VX-222 | NT | NT | NT | 4.4 | NT |
| BMS-790052 | NT | NT | NT | NT | 29.9 |
a
Fold change was expressed as the ratio of the EC50 for the mutant HCV replicon to the EC50 for the wild-type HCV replicon. Ratios were derived from the mean EC50 from two experiments. NT, not tested.