TABLE 2.

Key CI pharmacokinetic parameters for free plasma, subcutaneous tissue, cancellous bone, and cortical bone

Pharmacokinetic parametera	Mean (95% confidence interval) values in:
	Free plasma	SCTb	Cancellous bone	Cortical bone
AUC0–last (min · μg/ml)	3,437 (2,586–4,578)	1,809 (1,240–2,636)	1,296 (859–1,759)	919 (471–1,545)
Cmax (μg/ml)	51.4 (28.0–94.2)	12.7 (9.0–17.8)	6.1 (3.8–8.3)	2.5 (0.9–5.8)
Tmax (min)	2.7 (2.4–3.1)	16.6 (14.3–19.4)	39.9 (33.2–48.9)	52.1 (31.4–95.8)
fAUCtissue/fAUCplasma		0.53 (0.33–0.84)	0.38 (0.23–0.57)	0.27 (0.13–0.48)

^aAUC_0–last, area under the concentration-time curve from 0 to the last measured value; C_max, peak drug concentration; T_max, time to C_max; fAUC_tissue/fAUC_plasma, tissue penetration expressed as the ratio of free AUC tissue to free AUC plasma.

^bSCT, subcutaneous tissue.