TABLE 3.
Comparison of AUC and tissue penetration
| Parametera | Mean (95% confidence interval) for: |
P value | |
|---|---|---|---|
| STI | CI | ||
| AUC0–last (min · μg/ml) for: | |||
| Free plasma | 2,919 (2,615–3,263) | 3,437 (2,586–4,578) | 0.33 |
| SCT | 2,820 (1,986–3,986) | 1,809 (1,240–2,636) | 0.1 |
| Cancellous bone | 1,786 (1,557–2,049) | 1,296 (859–1,759) | 0.06 |
| Cortical bone | 1,319 (1,096–1,586) | 919 (471–1545) | 0.18 |
| fAUCtissue/fAUCplasma for: | |||
| SCT | 0.97 (0.67–1.39) | 0.53 (0.33–0.84) | 0.05 |
| Cancellous bone | 0.61 (0.51–0.73) | 0.38 (0.23–0.57) | 0.02 |
| Cortical bone | 0.45 (0.36–0.56) | 0.27 (0.13–0.48) | 0.07 |
a
AUC0–last, area under the concentration-time curve from 0 to the last measured value; fAUCtissue/fAUCplasma, tissue penetration expressed as the ratio of free AUC tissue to free AUC plasma.