TABLE 4.
Comparison of time above the MIC
| T>MIC for tissues by concn (μg/ml) | Mean (95% confidence interval) for (min): |
P value | |
|---|---|---|---|
| STI | CI | ||
| 0.5 | |||
| Plasma | 190 (178–205) | 465 (465–465) | <0.001 |
| SCT | 249 (187–332) | 464 (464–465) | <0.001 |
| Cancellous bone | 239 (215–266) | 463 (461–464) | <0.001 |
| Cortical bone | 335 (279–401) | 457 (450–460) | <0.001 |
| 1 | |||
| Plasma | 164 (153–177) | 465 (465–465) | <0.001 |
| SCT | 214 (162–283) | 464 (463–464) | <0.001 |
| Cancellous bone | 202 (183–224) | 460 (457–462) | <0.001 |
| Cortical bone | 268 (227–315) | 448 (0–455) | 0.12 |
| 1.5 | |||
| Plasma | 149 (139–160) | 465 (465–465) | <0.001 |
| SCT | 193 (147–255) | 463 (463–464) | <0.001 |
| Cancellous bone | 180 (165–199) | 457 (179–460) | <0.001 |
| Cortical bone | 227 (195–263) | 435 (0–448) | 0.07 |
| 2 | |||
| Plasma | 139 (129–149) | 465 (465–465) | <0.001 |
| SCT | 178 (136–234) | 463 (189–463) | <0.001 |
| Cancellous bone | 165 (151–182) | 453 (113–458) | 0.001 |
| Cortical bone | 199 (172–228) | 185 (0–439) | 0.9 |
| 4 | |||
| Plasma | 113 (104–121) | 465 (465–465) | <0.001 |
| SCT | 142 (109–185) | 118 (68–243) | 0.6 |
| Cancellous bone | 127 (117–139) | 61 (0–121) | 0.03 |
| Cortical bone | 126 (106–145) | 0 (0–122) | <0.001 |