TABLE 1.

Pooled MIC distributions and ECVs for the Cryptococcus neoformans-Cryptococcus gattii species complex and isavuconazole using the CLSI M27-A3-RPMI microdilution method^a

Species	No. of isolates	No. of isolates with an MICb (μg/ml) of:									ECV (μg/ml)c
		0.008	0.016	0.03	0.06	0.12	0.25	0.5	MIC range (μg/ml)	Mode (μg/ml)d	95%	97.5%
C. neoformans VNIe (AFLP1)	870	68	270	274	213	37	7	1	0.008–0.5	0.03	0.12	0.12
C. neoformans (nongenotyped)	438	10	135	170	96	19	6	2	0.008–0.5	0.03	0.06	0.12
C. gattiie	406	23	78	106	87	87	25	7	0.008–0.5	0.03	0.25	0.25

^aMICs were pooled from three or four of the six collaborating laboratories that submitted qualifying data for each cryptococcal group.

^bMICs as determined by the CLSI broth microdilution method using standard RPMI 1640 broth.

^cECVs comprising ≥95% and ≥97.5% of the statistically modeled MIC population.

^dMost frequent MIC.

^eC. gattii comprises the VGI through VGIV (also known as AFLP4 through AFLP7 and AFLP10) genotypes.