Table 2. Genes involved in lipid metabolism are overrepresented among transcripts altered by larval ethanol exposure.
| Gene Ontology Term | Total on Array | Number Changed | Percent Changed | Z Score | P |
|---|---|---|---|---|---|
| Phospholipase A1 activity | 11 | 6 | 55% | 10.1 | 0.0 |
| Pantetheine hydrolase activity | 3 | 3 | 100% | 8.5 | 0.0 |
| Glucosylceramidase activity | 3 | 3 | 100% | 9.9 | 0.0005 |
| Triglyceride lipase activity | 38 | 8 | 21% | 6.6 | 0.002 |
| Sphingolipid metabolic process | 22 | 4 | 18% | 4.2 | 0.036 |
Analysis using the GO Elite software package indicates that five categories of lipid metabolism genes are significantly overrepresented among the transcripts altered by at least four-fold in ethanol-reared third instar larvae. The Z score is a normal approximation to the hypergeometric distribution. P values were calculated using Fisher’s exact test.