Table 2.

Most strongly associated SNPs in the 3 meta-analyses

SNP	Chr	Pos	RA	NRA	RAF (min–max)	OR	95 % CI	P value	I 2	N	Gene(s)
European subjects aged ≥25 years
rs1401327	2	49900987	A	G	0.113–0.174	1.157	1.098–1.218	3.92E−08	0	31,694	NRXN1
rs17795388	2	49900356	G	A	0.113–0.174	1.157	1.098–1.218	4.16E−08	0	31,691	NRXN1
rs11690625	2	49908115	C	A	0.113–0.175	1.156	1.098–1.218	4.17E−08	0	31,731	NRXN1
rs17795358	2	49897928	A	G	0.113–0.173	1.156	1.097–1.218	4.94E−08	0	31,672	NRXN1
rs925931	2	49913312	C	T	0.113–0.173	1.148	1.090–1.210	2.06E−07	0	31,727	NRXN1
rs885560	2	49909442	G	A	0.113–0.175	1.146	1.088–1.207	2.46E−07	0	31,728	NRXN1
rs6708111	2	49878453	A	C	0.102–0.168	1.139	1.082–1.200	7.27E−07	0	31,531	NRXN1
rs11690252	2	49890187	T	G	0.230–0.342	1.105	1.060–1.151	2.59E−06	0	31,511	NRXN1
rs1878856	2	49877706	C	T	0.214–0.336	1.105	1.059–1.153	3.56E−06	0	31,603	NRXN1
rs12638075	3	1.42E + 08	C	T	0.014–0.024	1.376	1.200–1.577	4.69E−06	0	27,304	TRIM42/CLSTN2
rs2309717	4	27859336	A	C	0.089–0.170	1.143	1.083–1.206	1.02E−06	11.8	31,143	STIM2/PCDH7
rs2871434	4	29931147	T	A	0.095–0.154	1.140	1.079–1.204	2.66E−06	13.6	31,664	STIM2/PCDH7
rs12212674	6	22195053	A	T	0.496–0.621	1.099	1.058–1.142	1.45E−06	0	31,691	LINC00340
rs6901423	6	22194271	G	A	0.496–0.621	1.099	1.057–1.142	1.63E−06	0	31,689	LINC00340
rs4712652	6	22186594	A	G	0.495–0.687	1.097	1.055–1.141	3.13E−06	0	28,910	LINC00340
rs9366427	6	22204592	G	C	0.487–0.619	1.094	1.053–1.136	4.15E−06	0	31,773	LINC00340
rs4799964	18	26239477	G	T	0.020–0.048	1.267	1.152–1.394	1.16E−06	0	31,881	MIR302F
rs12607243	18	26229228	G	A	0.020–0.050	1.264	1.149–1.392	1.60E−06	0	31,882	MIR302F
European subjects aged <25 years
rs6688613	1	165218493	T	C	0.240–0.253	1.309	1.170–1.465	2.68E−06	0	5,640	MAEL
rs1327866	1	165219534	G	A	0.238–0.253	1.308	1.169–1.464	2.89E−06	0	5,640	MAEL
rs7550698	1	165217705	C	T	0.240–0.253	1.308	1.168–1.463	3.02E−06	0	5,640	MAEL
rs7528849	1	165221494	G	A	0.240–0.253	1.307	1.168–1.463	3.11E−06	0	5,640	MAEL
rs7518155	1	165221520	G	T	0.240–0.253	1.307	1.168–1.462	3.19E−06	0	5,640	MAEL
rs7545911	1	165214305	A	G	0.240–0.253	1.309	1.169–1.467	3.35E−06	0	5,640	MAEL
rs6682062	1	165216603	C	G	0.240–0.253	1.309	1.168–1.467	3.39E−06	0	5,640	MAEL
rs2296837	1	165225225	C	T	0.240–0.253	1.305	1.166–1.461	3.53E−06	0	5,640	MAEL
rs11578336	1	165225334	G	T	0.240–0.253	1.304	1.166–1.460	3.71E−06	0	5,640	MAEL
rs1366200	5	115349718	G	T	0.312–0.321	1.308	1.174–1.457	1.04E−06	48.7	5,640	AQPEP
rs17712049	7	48236741	C	T	0.875–0.904	1.569	1.295–1.902	4.39E−06	0	5,640	ABCA13
rs13257518	8	32755116	A	T	0.177–0.217	1.370	1.202–1.561	2.36E−06	15.7	5,640	NRG1
rs10503929	8	32733525	C	T	0.167–0.215	1.352	1.192–1.534	2.68E−06	32.3	5,640	NRG1
rs2975500	8	32724907	A	G	0.110–0.161	1.435	1.231–1.673	3.95E−06	0	5,640	NRG1
Asian adults
rs7534824	1	101394034	A	G	0.967–0.974	2.304	1.651–3.214	9.00E−07	0	4,812	LOC101928334
rs10496034	2	54998439	C	G	0.170–0.287	1.216	1.122–1.318	2.13E−06	0	8,780	EML6
rs428445	20	54469954	T	G	0.713–0.954	1.314	1.175–1.470	1.84E−06	0	8,908	CASS4/GCNT7
rs6999	20	54527308	A	G	0.713–0.957	1.303	1.164–1.459	4.30E−06	0	8,904	CASS4/GCNT7

The table shows all SNPs with P < 5.0E−06

RA risk allele, NRA non–risk (reference) allele, RAF risk allele frequency in each cohort, OR odds ratio, 95 % CI 95 % confidence interval of odds ratio, I ² heterogeneity statistic, N total sample size