Figure 7.
Model of ciliary sAC (A) Human model depicts sACex5v2-ex12v2 interaction with a C1 donor that is targeted to cilia to regulate CBF in airway epithelial cells. Targeting depends on appropriate sequences: exons 5v2–7 only will allow ciliary expression; if exons 2–4 are present, as in sACfl, no ciliary localization occurs. The putative associating sites between the unknown C1 donor and sACex5v2-ex12v2 are purely speculative. (B) Rescue of sAC-mediated regulation of CBF in C2 KO mice using the human sACex5v2-ex12v2.