Figure 4.
Photomicrographs of rat vestibular hair cells in the macula of utricles labeled with Alexa Fluor 488 conjugated phalloidin. (A) Most hair cells were visible 48 h after 10 µM carboplatin treatment. (B) Tangling and breaking cilia were detected 48 h post-50 µM carboplatin. (C) Visible damage on the cuticular plate of hair cells was found 48 h after 100 µM carboplatin cultures. (D) 50 µM carboplatin treatment for 48 h resulted in massive destruction of hair cells. (E) Most hair cells were intact 48 h after 1000 µM carboplatin treatment.