Table 1. Aqueous Instability of Compound 1 under Various Conditionsa.
Stability of 1 tested at 2 mg/mL in 1:1 H2O/cosolvent.
Purity evaluated by HPLC using 10 mM aq. NH4OAc/MeCN gradient on a 4.6 × 50 mm 4.6 μm C18 column with 220 nm UV detection.
Stability of 1 tested at 2 mg/mL in 1:1 H2O/cosolvent.
Purity evaluated by HPLC using 10 mM aq. NH4OAc/MeCN gradient on a 4.6 × 50 mm 4.6 μm C18 column with 220 nm UV detection.