. 2014 Sep 24;6(1):68–72. doi: 10.1021/ml500315b

Table 1. Naphthyl Modification Improves Selectivity^a.

graphic file with name ml-2014-00315b_0006.jpg

Cpd	R	IRE1α Enz IC₅₀ (μM)	XBP1-Luc IC₅₀ (μM)	Aurora p-histone H3 IC₅₀ (μM)	JNK3 Enz IC₅₀ (μM)^b (fold)^c
1	H	0.071	0.27	16	0.35 (4.9)
2	Me	0.014	0.20	>50^b	0.71 (51)

Unless noted otherwise, data represent an average of ≥2 separate determinations.

Data represent a single determination.

Fold selectivity versus IRE1α enzyme.

Table 1. Naphthyl Modification Improves Selectivitya.