Table 2. Comparison of General Properties of Kinase Inhibitors^a.

	type I	type II	type III	type IV	type V
DFG conformation	in	out	out	ND	in
binding region	ATP-binding site	ATP-binding site and neighboring region	neighboring region	allosteric site not adjacent to ATP-binding site	ATP-binding site and neighboring region
ATP competitive	yes	yes	no	no	yes
selectivity	usually low	high	high	high	high
association kinetics	rapid	slow	slow	ND	rapid
dissociation kinetics	rapid	slow	slow	ND	relatively slow

^aND, not determined.