Table 2. Kinase Selectivity of MELK-T1 (7).
kinasea | % inh @ 1 μM (IC50 nM) |
---|---|
MELK | 97 (23) |
Flt3 | 90 (18) |
CAMKIIδ | 60 (810) |
Mnk2 | 59 (760) |
CAMKIIγ | 55 (1000) |
MLCK | 54 (1000) |
AMPKα1 | 5 |
AMPKα2 | –12 |
Millipore kinase panel; for details, see Supporting Information