Figure 6.

Proliferation of MDA-MB-231 cells in the presence of various concentrations and combinations of MDC, BPTES, and 968. (A) Histograms showing key data points collected from dose curves for MDA-MB-231 cells treated with BPTES, MDC, or BPTES and MDC. The Y-axis represents the number of cells in culture after 6 days of the indicated drug treatments, while the X-axis is positioned at the starting number of cells. Values indicated with * were calculated from dose curves, and error bars represent the standard deviation from the nearest experimental measurement. (B) Effects of 968 and MDC (black bars), 968, MDC, and 6.6 mM dimethyl-α-ketoglutarate (white bars), or MDC alone (gray bars) on the growth of MDA-MB-231 cells. Cells were treated for 6 days with 968 and/or MDC added at the indicated fractions of their IC₅₀ values (4.2 μM for 968 and 60 μM for MDC).